FIELD: biochemistry.
SUBSTANCE: invention relates to biochemistry. Described oligonucleotides with length from 15 to 30 nucleotides, containing at least one modification, note here that said at least one modification selected from: at least one modified sugar fragment; at least one modified internucleotide linkage; at least one modified nucleotide; and their combinations. Note here that said oligonucleotides are specifically hybridized with natural antisense polynucleotide of gene p63, increasing such way gene expression of tumor protein 63 (p63) in vivo or in vitro, and have sequence at least at 90% identical to sequence, reverse complementary to a section within from 1 to 288 nucleotide sequence SEQ ID NO: 2, or have sequence, at least at 90% identical to a section of sequence SEQ ID NO: 1. Present invention also relates to use of such antisense oligonucleotides for treatment of diseases and disorders associated with expression of p63.
EFFECT: invention extends the range of products for treating diseases and disorders associated with expression of p63.
33 cl, 1 dwg, 2 ex
