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2 570 906

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IPC

C07D235/14(2006-01-01)

A61K31/4184(2006-01-01)

A61P31/12(2006-01-01)

(21) (22)

Application

2012123803/04, 2012-06-07

(24)

Start date

2012-06-07

(22)

Actual filing date

2012-06-07

(45)

Published

2015-12-20

(72)

Inventor

Zarubaev Vladimir ViktorovichDivaeva Ljudmila NikolaevnaKarpinskaja Ljubov' AntonovnaKiselev Oleg IvanovichMorkovnik Anatolij Savel'Evich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Institut Grippa" Ministerstva Zdravookhranenija I Sotsial'Nogo Razvitija Rossijskoj Federatsii Grippa)Federal'Noe Gosudarstvennoe Avtonomnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Federal'Nyj Universitet"

1-[ω-ARYLOXYALKYL(BENZYL)]-SUBSTITUTED 2-AMINOBENZIMIDAZOLES, HAVING ACTIVITY ON INFLUENZA VIRUS Russian patent published in 2015 - IPC C07D235/14 A61K31/4184 A61P31/12

Abstract RU 2570906 C2

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and particularly to novel benzimidazole derivatives of formula 1a-f:

where a, b X=N, R=4-ClC₆H₄OCH₂CH₂, Hal^- is absent, a) R¹ = 2-furoyl, b) R¹ = 2-thenoyl; c-h X=N⁺CH₂R², R¹=H, c) R=3,4-Cl₂C₆H₄CH₂, R²=CONH₂; Hal=Cl; d) R=4-FC₆H₄OCH₂CH₂, R²=CONH₂; Hal=Cl; e) R=3,4-Cl₂C₆H₄CH₂, R²=CH₂OH; Hal=Cl; f) R=4-ClC₆H₄OCH₂CH₂, R²=CH₂OH; Hal=Cl; g) R=4-FC₆H₄OCH₂CH₂CH₂, R²=CH=CH₂; Hal=Br; h) R=4-(CH₃)₃CC₆H₄OCH₂CH₂, R²=CH=CH₂; Hal=Br.

EFFECT: obtaining novel compounds having anti-influenza virus activity.

1 tbl, 10 ex

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RU 2 570 906 C2

Authors

Zarubaev Vladimir Viktorovich

Divaeva Ljudmila Nikolaevna

Karpinskaja Ljubov' Antonovna

Kiselev Oleg Ivanovich

Morkovnik Anatolij Savel'Evich

Dates

2015-12-20—Published

2012-06-07—Filed