FIELD: chemistry.
SUBSTANCE: invention relates to molecular biology, pharmacology and medicine. Disclosed is an oligopeptide KNNMINNDLG isolated from oligopeptide PB1 (531-540), which is active against both human influenza H1N1 (EC50=28.6 mcg/ml) and bird influenza H5N2 (EC50=35.3 mcg/ml).
EFFECT: invention can be used for vaccination against influenza virus subtypes H1 and H5.
2 cl, 1 tbl, 2 dwg, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PEPTIDE-BASED COMPOSITION SUPPRESSING REPLICATION OF INFLUENZA A VIRUS | 2018 |
|
RU2695336C1 |
| 1-[ω-ARYLOXYALKYL(BENZYL)]-SUBSTITUTED 2-AMINOBENZIMIDAZOLES, HAVING ACTIVITY ON INFLUENZA VIRUS | 2012 |
|
RU2570906C2 |
| UNIVERSAL AVIAN INFLUENZA VIRUS VACCINE | 2007 |
|
RU2358981C2 |
| STRAIN A/GOOSE/KALMYKIA/813/16 H5N8 VIRUS AVICUM BIRD INFLUENZA VIRUS AVICUM INFLUENZA TYPE A AND SUBSTITUTE H5 FOR CONTROL OF ANTIGEN AND IMMUNIZING ACTIVITY OF VACCINE AGAINST AVIAN INFLUENZA AND FOR THE MANUFACTURE OF BIOPREPARATIONS FOR DIAGNOSTICS AND SPECIFIC PREVENTION OF INFLUENZA BIRDS OF TYPE A OF SUBSTITUTE H5 | 2017 |
|
RU2647566C1 |
| USING 1,7,7-TRIMETHYLBICYCLO[2,2,1]HEPTAN-2-YLIDENE-AMINOETHANOL AS INFLUENZA VIRUS REPRODUCTION INHIBITOR | 2013 |
|
RU2530554C1 |
| IMINE COMPOUNDS OF CAMPHOR - EFFECTIVE INHIBITORS OF REPRODUCTION OF FLU VIRUS (A/California/07/09 (H1N1)pdm09 STRAIN) | 2014 |
|
RU2554934C1 |
| PHARMACEUTICAL SALTS OF AMINOBICYCLO[2,2,1]HEPTANE AS NF-KB TRANSCRIPTION FACTOR INHIBITORS WITH ANTIVIRAL ACTIVITY (VERSIONS) AND USING THEM | 2009 |
|
RU2448692C2 |
| RECOMBINANT STRAIN OF A/PR8-NS124-Luc INFLUENZA VIRUS AND METHOD FOR EVALUATING POST-VACCINAL NEUTRALIZING ANTIBODIES USING BIOLUMINESCENT DETECTION | 2019 |
|
RU2759054C2 |
| USE OF FULLERENOLS C60(OH)18-24 AND C60(OH)30-38 AS ANTIVIRAL PREPARATIONS | 2011 |
|
RU2472496C2 |
| IMINE DERIVATIVES OF CAMPHOR, CONTAINING AROMATIC OR HETEROAROMATIC FRAGMENT - INHIBITORS OF REPRODUCTION OF FLU VIRUS (STRAIN A/CALIFORNIA/07/09(H1N1)pdm09) | 2015 |
|
RU2607451C1 |
