METHOD OF TREATING INFERTILITY ACCOMPANYING CHRONIC ENDOMETRITIS WITH ENDOMETRIAL HYPOPLASIA Russian patent published in 2015 - IPC A61N7/00 A61K31/167 A61K38/08 A61P15/08 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly gynaecology, and concerns treating infertility accompanying chronic endometritis with endometrical hypoplasia. A method involves an integrated therapy, which involves intrauterine administration of medicinal solutions and an endometrial exposure to low-frequency ultrasound (LFUS). The LFUS procedures are performed within three courses: the first course uses 0.05% chlorhexidine in the uterine cavity. The second and third courses provide using Imunofan in sterile normal saline in ratio 1/125. The therapeutic course involves performing procedures once a day, daily, from 5 to 10 procedures. The therapeutic courses are alternated with a treatment-free period of 2-3 menstrual cycles. The procedures in the therapeutic course start on the 5-9^th day of menstrual cycle. The procedure involves providing the continuous intrauterine circulation of the medicinal solution with maintaining the pressure less than atmospheric pressure. The procedure is performed at ultrasonic vibration frequency 25 kHz, LFUS wave guide vibration amplitude 60-120 mcm, medicinal solution flow 100-150 ml/min, exposure 3-5 min, amount of infusion 200-300 ml.

EFFECT: method provides complete uterine sanitation, activation of regeneration and active growth of the endometrium with improved treatment comfort and safety, minimum time and facilities required.

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