METHOD FOR RECOVERY OF ENDOMETRIUM RECEPTIVITY IN WOMEN WITH UTERINE INFERTILITY WITH THE USE OF A CAVITATED SOLUTION OF GRANULOCYTE COLONY-STIMULATING GROWTH FACTOR Russian patent published in 2018 - IPC A61N7/00 A61M3/04 A61M31/00 A61K31/7004 A61K38/18 A61P15/08 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, particularly to obstetrics and gynecology, and can be used to increase the receptivity of the endometrium in patients with uterine infertility in the presence of a thin refractory endometrium in preparation for in vitro fertilization. For this purpose, a procedure of low-frequency ultrasonic cavitation irrigation of the uterine cavity is performed during the period of the implantation window on the 7th day after ovulation with the 28-day menstrual cycle preceding the in vitro fertilization. In this case, as a disclosed medicinal medium, granulocyte colony-stimulating growth factor Filgrastim^® in a dose of 300 mcg/ml in dilution of 6 ml of the drug per 200 ml of a 5 % solution of dextrose. Duration of the procedure is 5 minutes, the frequency of ultrasonic waves is 25 kHz.

EFFECT: method provides an increase in the implantation potential of the endometrium and the frequency of pregnancy by increasing the bioavailability of the drug with its intrauterine injection as a result of its absorption in the basal layer of the endometrium, which is the main point of application of the action of the granulocyte colony-stimulating growth factor.

1 cl, 3 ex