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(11)

2 635 917

(13)

(51)

IPC

C07D487/04(2006-01-01)

A61K31/5025(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2014153627, 2013-06-03

(24)

Start date

2013-06-03

(22)

Actual filing date

2013-06-03

(45)

Published

2017-11-17

(72)

Inventor

Takeda YasuyukiJosikava KendziKagosima JosikoYamamoto YukoTanaka RioitiTominaga YuitiKiga MasakiKhamada Josito

(73)

Holder

Dajiti Sankio Kompani, Limited

IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AS KINASE INHIBITORS Russian patent published in 2017 - IPC C07D487/04 A61K31/5025 A61P35/00

Abstract RU 2635917 C2

FIELD: pharmacology.

SUBSTANCE: invention relates to a compound of the general formula

having an imidazo[1,2-b]pyridazine structure, or a pharmacologically acceptable salt thereof and a pharmaceutical composition comprising such a compound. In the formula R¹, G, T, Y¹, Y², Y³ and Y⁴ have values indicated in the claims.

EFFECT: compounds of the formula are useful for treatment of a tumour through an inhibitory effect on the enzymatic activity of its ROS1 kinase and the inhibitory effect on the enzyme kinase NTRK.

48 cl, 25 tbl, 150 ex

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RU 2 635 917 C2

Authors

Takeda Yasuyuki

Josikava Kendzi

Kagosima Josiko

Yamamoto Yuko

Tanaka Rioiti

Tominaga Yuiti

Kiga Masaki

Khamada Josito

Dates

2017-11-17—Published

2013-06-03—Filed