NOVEL NAPHTHYRIDINE DERIVATIVES AND THEREOF APPLICATION AS KINASE INHIBITORS Russian patent published in 2016 - IPC C07D471/04 A61K31/4745 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to naphthyridine derivatives of general formula I in which R1-R6 substituents have the following values: R1 represents NR7R8, R2 represents hydrogen, and R3 represents hydrogen, where R7 represents hydrogen, and R8 can represent -C(Y)NR9R10, where Y represents O, S, and R9 hydrogen and R10 can represent (i) non-substituted saturated C_1-6-alkyl, possibly substituted with non-substituted C₆-aryl, (ii) non-substituted C₆-aryl, R4 represents hydrogen, R5 can represent (i) C₆-aryl, substituted with saturated C_1-6-alkoxy or hydroxyl, (ii) C₅-heteroaryl, containing 2 nitrogen atoms, substituted with saturated C_1-6-alkyl, (iii) NR15R16, where R15 represents hydrogen, and R16 represents C₆-aryl, substituted with saturated C_1-6-alkoxy, and R₆ represents hydrogen; and their physiologically acceptable salts, which are kinase modulators.

EFFECT: obtaining novel compounds.

12 cl, 1 tbl, 10 ex