METHOD FOR OBTAINING N-ACETYLGLUCOSAMINYL-N-ACETYLMURAMYL-L-ALANYL-D-GLUTAMIC ACID Russian patent published in 2016 - IPC A61K31/00 

FIELD: chemistry.

SUBSTANCE: method for obtaining N-acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-glutamic acid includes condensation of unprotected derivative of muramic acid with protected linear dipeptide, catalytic hydrogenolysis of synthesised dibenzyl ether of N-acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-glutamic acid (DBE), carried out over palladium catalyst, which is characterized by the fact that catalystic hydogenolysis is realised in ethyl alcohol medium with application of catalyst promoter - hydrazine hydrate (HH) and reducer - formic acid (FC) with the following ratio of reagents: ratio by weight {DBE:Pd} = {1:0.100-0.500}; ratio in weight percent {Pd:HH} = {100:0.5-1.5}; ratio in molar equivalents {DBE:FC} = {1:2-4}.

EFFECT: application of claimed invention ensures higher selectivity of catalytic process of formula target product formation, responsible for minimisation of undesirable admixtures in it, and higher output of target product in comparison with known methods.

2 tbl, 6 ex, 4 dwg