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2 124 022

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Application

97105811/04, 1997-04-10

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Actual filing date

1997-04-10

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Published

1998-12-27

(72)

Inventor

Zhmak M.N.Vol'Pina O.M.Kuprijanova M.A.Andronova T.M.Makarov E.A.Romanova V.S.Parnes Z.N.Vol'Pin M.E.Ivanov V.T.

(73)

Holder

Institut Bioorganicheskoj Khimii Im.M.M.Shemjakina I Ju.A.Ovchinnikova Ran

GLYCOPEPTIDE FULLERENE DERIVATIVE SHOWING ADJUVANT ACTIVITY Russian patent published in 1998 - IPC

Abstract RU 2124022 C1

FIELD: medicine, biotechnology, veterinary science. SUBSTANCE: invention proposes a fullerene derivative of glycopeptide of the formula (I): GlcNAc-MurNAc-Ala-D-iGln--[Lys-e-CO(CH2)5NHC6O-H], showing adjuvant activity. Substance is obtained by synthesis of aminocaproic acid fullerene derivative and the following its addition reaction to glycopeptide lysine derivative. Synthesized compound shows high adjuvant property at low doses (1-10 nM per an animal). At high dose (1 mg/mouse) this substance does not show lethal or toxic effects. Mice (strain BALB/c, females) are used as experimental animals. EFFECT: enhanced adjuvant activity of compound. 1 ex, 1 tbl

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RU 2 124 022 C1

Authors

Zhmak M.N.

Vol'Pina O.M.

Kuprijanova M.A.

Andronova T.M.

Makarov E.A.

Romanova V.S.

Parnes Z.N.

Vol'Pin M.E.

Ivanov V.T.

Dates

1998-12-27—Published

1997-04-10—Filed

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