FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to biochemistry, particularly to nucleic acid molecules for target gene expression modulation. What is declared is a two-stranded nucleic acid molecule for heat shock protein 47 (hsp47) gene expression inhibition. There are also presented a composition containing the above nucleic acid molecule, and a method of treating a patient suffering a hsp47-associated disease.
EFFECT: invention may be used for treating hsp47-associated conditions and disorders, such as hepatic fibrosis, pulmonary fibrosis, abdominal fibrosis and renal fibrosis.
25 cl, 27 dwg, 31 tbl, 10 ex
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