iRNA-MEDIATED INHIBITION OF TUMOUR NECROSIS FACTOR-( RELATED CONDITIONS Russian patent published in 2012 - IPC C12N15/11 A61K31/713 C07H21/02 

Abstract RU 2469090 C2

FIELD: medicine.

SUBSTANCE: method is implemented by introducing a composition containing an effective amount of interfering RNA of the length of 19-27 nucleotides, and a pharmaceutically acceptable carrier wherein interfering RNA contains a sense nucleotide chain, and an antisense nucleotide chain wherein a complementary™ site makes at least 19 continuous nucleotides. There are also presented methods of treating a TNF-α related condition in a subject in need thereof, and a composition for treating the TNF-α related eye condition.

EFFECT: invention may be effectively used in treating the patients suffering a TNF-α related condition or having a risk of such developing condition.

23 cl, 1 dwg, 2 tbl, 1 ex

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RU 2 469 090 C2

Authors

Janni Dzhon M.

Chatterton Dzhon E.

Senchina Dajan Mishell'

Gamach Dehniel A.

Miller Stiven T.

Dates

2012-12-10Published

2007-05-17Filed