FIELD: biotechnology.
SUBSTANCE: pharmaceutical composition for prevention or treatment of a disease associated with hsp47 is described, comprising a drug carrier and a double-stranded nucleic acid molecule, wherein the drug carrier comprises a retinoid and a lipid, wherein the double-stranded nucleic acid molecule comprises a 5' (N)x-Z 3' (antisense strand) 3' Z'-(N')y-z" 5' (sense strand) structure, where each N and N' is a nucleotide that is unmodified, or modified, or a non-standard component. Also a method for this composition application for treatment of diseases associated with hsp47 expression, including fibrosis, is described.
EFFECT: invention expands the arsenal of means intended for treatment of diseases associated with hsp47 expression.
49 cl, 32 dwg, 13 tbl, 23 ex
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