MODIFIED SV F PROTEINS OF SV AND METHODS OF USING THEM Russian patent published in 2014 - IPC A61K39/00

Abstract RU 2531510 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to virology, immunology, molecular biology and gene engineering. What is presented is a respiratory syncytial virus (RSV) fused (F) protein for eliciting an immune response, wherein the above RSV F protein contains a deletion of one or more amino acids of a fusion domain, wherein the above fusion domain corresponds to amino acids 137-154 of RSV F wild-type protein (SEQ ID NO:2); and an inactivated primary site of furin splitting, wherein the primary site of furin splitting corresponds to amino acid 131-136 of RSV F wild-type protein (SEQ ID NO: 2), wherein the inactivation is performed by mutation; as well as nucleic acid coding the given protein, a cell, a vaccine composition, a micelle and a virus-like particle.

EFFECT: invention can be used for treating and preventing RSV infection.

25 cl, 22 dwg, 11 ex

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RU 2 531 510 C2

Authors

Pushko,Piter

U,Injun'

Massar,Majkl

Lju,E

Smit,Gejl

Chzhou,Bin'

Dates

2014-10-20—Published

2009-12-09—Filed