FIELD: biotechnology.
SUBSTANCE: proposed group of inventions relates to biotechnology. Disclosed are methods of producing a rabies virus-like particle (VLP) in a plant or part of a plant, virus-like particles (VLP) obtained using same, a composition comprising said virus-like particles (VLP), and a method for inducing immunity to an infection caused by a rabies virus. Said rabies virus-like particles contain native rabies virus glycoprotein (G) and a lipid derived from the plant's plasma membrane, wherein the native rabies virus glycoprotein (G) may contain plant-specific N-glycans or modified N-glycans.
EFFECT: disclosed rabies virus-like particles and composition containing same can be used in medicine to induce an immune response in a subject against a rabies virus.
25 cl, 31 dwg, 2 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PRODUCTION OF VIRUS-LIKE PARTICLES IN PLANTS | 2011 |
|
RU2655431C2 |
| INCREASING VARIABLE-FREE PARTICLES OUTPUT IN PLANTS | 2012 |
|
RU2682752C2 |
| OBTAINING PICORNAVIRUS-LIKE PARTICLES IN PLANTS | 2013 |
|
RU2693431C2 |
| OBTAINING VIRUS-LIKE PARTICLES OF INFLUENZA VIRUS IN PLANTS | 2014 |
|
RU2742607C1 |
| OBTAINING VIRUS-LIKE PARTICLES OF INFLUENZA VIRUS IN PLANTS | 2014 |
|
RU2705555C2 |
| HEMAGGLUTININ-CONTAINING CHIMERIC VIRUS-LIKE PARTICLES, SIMILAR TO PARTICLES OF FLU VIRUS | 2010 |
|
RU2569195C9 |
| HEMAGLUTININ MUTANTS OF THE INFLUENZA VIRUS | 2019 |
|
RU2800938C2 |
| ENHANCER ELEMENTS CPMV | 2015 |
|
RU2699982C2 |
| IMMUNOGENIC EPITOPE OF INFLUENZA VIRUS | 2009 |
|
RU2546872C2 |
| VIRUS-LIKE PARTICLES (VLP) OF RABIES VIRUS GLYCOPROTEIN | 2011 |
|
RU2575800C2 |
