FIELD: medicine; pharmacology.
SUBSTANCE: invention relates to a pharmaceutical composition for prevention or treatment of macular degeneration containing benzopyrazine derivatives of formula 1 or their pharmaceutically acceptable salts as an active component, where R1 corresponds to H, CN, NO2 or NH2, R2 corresponds to 
, R3 and R4 are independent from each other and correspond to H, Cl, Br, F, C1~C3 alkyl radical with linear or branched chain, ORb, CF3, OCF3, NO2 or CO2Rb, Ra corresponds to (C)1~ C4 alkyl radical with linear or branched chain, Rb corresponding to H or C1~C3 alkyl radical, and * corresponds to chiral center. Invention also relates to preparation of eye drops based on the compound of formula 1.
EFFECT: obtaining a pharmaceutical composition based on benzopyran effective in treatment of macular degeneration.
9 cl, 12 dwg, 3 tbl, 10 ex
<Formula 1>
| Title | Year | Author | Number |
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| DERIVATIVES OF BENZOPYRANE SUBSTITUTED WITH SECONDARY AMINES COMPRISING TETRAZOLE, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF | 2003 |
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| EYE DROPS IN FORM OF SOLUTION CONTAINING BENZOPYRAN DERIVATIVE OR ITS PHARMACEUTICALLY ACCEPTABLE SALT | 2019 |
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| DERIVATIVES OF CYCLOHEXANE OR TETRAHYDROPYRANE OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, OR HYDRATES, OR SOLVATES OF THESE COMPOUNDS, OR THEIR SALTS, INTERMEDIATE COMPOUNDS FOR THEIR SYNTHESIS AND FUNGICIDE AGENT | 1992 |
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