FIELD: chemistry.
SUBSTANCE: invention relates to the novel polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride - crystalline forms I, III, IV and V, as well as to crystalline form II in the form of a hydrate. The said crystalline forms separately or in a combination possess the properties of the inhibitor of the reuptake of 5-hydroxytryptamine (5-OT) and/or arterenol (NA) and can be used for manufacturing a medication for the treatment of diseases, selected from the diseases of the central nervous system, for instance, depression. The crystalline forms are characterised by the indices of powder roentgenogram, melting point and a DSC spectrum. The invention also relates to methods for obtaining the crystalline forms and a thereof-based pharmaceutical composition.
EFFECT: improvement of properties.
18 cl, 22 dwg, 10 tbl, 8 ex
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