COMPOUND, CERTAIN NOVEL FORMS THEREOF, PHARMACEUTICAL COMPOSITIONS BASED THEREON AND METHODS OF PRODUCTION AND USE Russian patent published in 2014 - IPC C07D403/12 A61K31/506 A61P9/00 A61P35/00 

Abstract RU 2507203 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a novel compound - N-(2-(dimethylamino)ethyl)-1-(3-((4-((2-methyl-1H-indol-5-yl)oxy)pyrimidin-2-yl)amino)phenyl)methanesulphonamide of formula A and/or a pharmaceutically acceptable salt thereof, having KDR and/or FGFR1 inhibitor properties. The compounds can be used to treat disorders associated with KDR mediated angiogenesis, such as cancer and age-related macular degeneration, or various cancerous diseases which respond to FGFR1 inhibition. Compound (A) corresponds to the structural formula (A) given below.

EFFECT: invention relates to crystalline forms I and II of said compound A and methods for production thereof, pharmaceutical compositions and a method of treatment.

38 cl, 8 dwg, 14 ex

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RU 2 507 203 C1

Authors

Su Vej-Guo

Chzhan Vehjkhan'

Tszja Khun

Tsuj Jujmin'

Zhehn' Junsin'

Saj Jan

U Chzhehn'Pin

Li Vehn'Tsze

Shao Tszjanjun

Tjan' Chzhehn'Pin

Dates

2014-02-20Published

2010-11-23Filed