FIELD: chemistry.
SUBSTANCE: invention concerns novel polymorphous and amorphous forms of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-on phosphate of the formula (I) and pharmaceutical composition based on them, with modulation effect on poly(adenosine-5-diphosphate(AOP)-ribose)polymerase activity.
EFFECT: obtaining novel polymorphous and amorphous forms of compound phosphate of the formula (I) and pharmaceutical composition based on them for the purpose of treatment of disease state conditioned by poly(AOP ribose)polymerase activity, including such disease as cancer.
8 cl, 3 tbl, 24 dwg, 8 ex
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Authors
Dates
2009-05-20—Published
2005-09-12—Filed