POLYMORPHOUS AND AMORPHOUS FORMS OF 8-FLUORO-2-{4-[(METHYLAMINO)METHYL]PHENYL}-1,3,4,5-TETRAHYDRO-6H-AZEPINE[5,4,3-CD]INDOL-6-ON PHOSPHATE Russian patent published in 2009 - IPC C07D487/06 A61K31/55 A61P35/00 A61P25/00 

Abstract RU 2355691 C2

FIELD: chemistry.

SUBSTANCE: invention concerns novel polymorphous and amorphous forms of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-on phosphate of the formula (I) and pharmaceutical composition based on them, with modulation effect on poly(adenosine-5-diphosphate(AOP)-ribose)polymerase activity.

EFFECT: obtaining novel polymorphous and amorphous forms of compound phosphate of the formula (I) and pharmaceutical composition based on them for the purpose of treatment of disease state conditioned by poly(AOP ribose)polymerase activity, including such disease as cancer.

8 cl, 3 tbl, 24 dwg, 8 ex

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RU 2 355 691 C2

Authors

Liu Dzhia

Najjar Naresh

Guo Ming

Vu Zhen-Ping

Borer Bennett Shaplin

Shrirangam Aparna Nadig

Mitchell Mark Brajan

Li Ji

Chu Dzhan-Dzhon

Dates

2009-05-20Published

2005-09-12Filed