ARTIFICIAL GENES CODING EV.CTL AND EV.Th PROTEINS-IMMUNOGENS, RECOMBINANT PLASMID DNA pEV.CTL AND EV.Th, PROVIDING EXPRESSION OF ARTIFICIAL GENES, AND ARTIFICIAL T-CELL POLYEPITOPE PROTEINS-IMMUNOGENS EV.CTL AND EV.Th CONTAINING EPITOPES OF EBOLA VIRUS ANTIGENS, USED TO CREATE AN EBOLA VIRUS VACCINE Russian patent published in 2020 - IPC A61K39/12 

FIELD: biotechnology.

SUBSTANCE: invention refers to biotechnology and molecular biology. Disclosed are artificial genes used to create an Ebola virus vaccine, coding artificial T-cell protein immunogen EV.CTL and T-cell protein immunogen EV.Th respectively, with Ebola virus antigen properties, and having sequence SEQ ID NO: 3 long with 1,881 base pairs and SEQ ID NO: 4 with length of 1,146 base pairs, respectively, containing at 5'-end the Kozak's sequence (CCGCCACC) and the XbaI and EcoRI restriction endonuclease site, respectively, and at 3'-end there are three stop codon (TGATGATAG) and a site of restriction endonuclease ApaI, as well as corresponding recombinant plasmids and polyepitope proteins-immunogens.

EFFECT: invention can be applied in medicine.

6 cl, 10 dwg, 2 tbl, 3 ex