FIELD: medicine, pharmaceutics.
SUBSTANCE: modified release pharmaceutical composition contains (1) (R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetoacetanilide or a pharmaceutically acceptable salt thereof, (2) at least one additive which facilitates the water intrusion into the pharmaceutical composition and has a solubility such as a volume of water required to dissolve 1 g of the additive is equal to 10 ml or less, and (3) a hydrogel-forming polymer having an average molecular weight of approximately 100000 or more, or a viscosity of 12 mPa·s or more in 5% aqueous solution at 25°C.
EFFECT: invention provides the release of the above active agent not involved in the effect of dietary intake.
23 cl, 1 dwg, 4 tbl, 17 ex
Title | Year | Author | Number |
---|---|---|---|
PHARMACEUTICAL COMPOSITION FOR CONTROLLED RELEASE OF ACTIVE SUBSTANCES AND METHOD FOR ITS PREPARING | 2003 |
|
RU2291711C2 |
CONTROLLED RELEASE SOLID PREPARATION | 2006 |
|
RU2496480C2 |
PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION | 2010 |
|
RU2580652C2 |
METHOD OF OBTAINING OF PREPARATION WITH COVERING | 2004 |
|
RU2359671C2 |
SYSTEM FOR PROLONGED RELEASE OF SOLUBLE DRUG | 2002 |
|
RU2322263C2 |
HYDROGEL PREPARATION EXHIBITING THE SUSTAINED DRUG RELEASE | 1993 |
|
RU2121830C1 |
METHOD OF ANTIDEMENTIA DRUG STABILISATION | 2005 |
|
RU2401125C2 |
STABLE PERORAL GEL-FORMING PHARMACEUTICAL COMPOSITION, METHOD FOR IT PREPARING, METHOD FOR PREVENTION ALTERATION IN MEDICINAL AGENT RELEASING, METHOD FOR ENHANCEMENT OF PHYSICAL STABILITY OF PERORAL COMPOSITION | 2000 |
|
RU2220715C2 |
SLOW-RELEASE MATRIX PREPARATION CONTAINING BASE AGENT OR ITS SALT AND METHOD FOR MAKING THEREOF | 2005 |
|
RU2390354C2 |
COMPOSITION CONTAINING FINE DISPERSED LONG RELEASING PARTICLES FOR QUICK-DISPOSABLE IN BUCCAL CAVERN TABLETS | 2002 |
|
RU2245136C2 |
Authors
Dates
2013-10-20—Published
2009-09-28—Filed