FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine and concerns a medicament for therapeutic treatment and/or ameliorating sepsis, which comprises thrombomodulin as an active ingredient. Medicament is to administer to a patient with severe sepsis accompanied with one or more organ dysfunctions, with one or more organ dysfunctions selected from the group consisting of liver dysfunction, kidney dysfunction, respiratory organ dysfunction, and circulatory organ dysfunction wherein a value of International Normalized Ratio (INR) of a plasma specimen obtained from said patient is more than 1.4. Also proposed medicament for reducing mortality in patients with sepsis.
EFFECT: group invention provides a reduction of mortality in patients with sepsis, namely in patients with severe sepsis, accompanied by one or more liver dysfunction, kidney, respiratory organs or circulation organs.
30 cl, 4 tbl, 8 ex
