METHOD OF PRODUCING 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL) PHENYL] AMINO} -CARBONYL) AMINO]-3-FLUOROPHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, SALTS AND MONOHYDRATE THEREOF Russian patent published in 2016 - IPC C07D213/81 A61K31/4412 A61P35/00 

Abstract RU 2581585 C2

FIELD: chemistry.

SUBSTANCE: invention relates to the method of producing the monohydrate of the compound of formula by treating the compound of formula with the compound of formula in a reaction mixture, followed by treating the dissolved compound of formula (I) with an acid to form the salt of the compound of formula (I), which precipitates from the solution containing the dissolved compound of formula (I), and then treating the said salt of the compound of formula (I) with an aqueous basic solution to precipitate the monohydrate of the compound of formula (I).

EFFECT: improved method.

13 cl, 1 ex

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RU 2 581 585 C2

Authors

Shtil Jurgen

Khajlmann Verner

Legers Mikhael

Reze Joakhim

Gottfrid Mikhael

Vikhmann Zaskia

Dates

2016-04-20Published

2011-04-08Filed