FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to compounds of formula
, where each R1 and R2 is independently selected from hydrogen, methyl, ethyl, or R1 and R2 form four-, five- or six-member ring together with amide nitrogen, said ring optionally containing oxygen atom; X represents bromine or chlorine; as well as to their pharmaceutically acceptable salts and enantiomers of formula I compounds and their salts. Invention also relates to application of compound on any of i.i. 1-21, to pharmaceutical composition, as well as to selected from the group compounds.
EFFECT: obtaining novel biologically active compounds, possessing antagonistic activity with respect to receptor NK1/NK2/NK3.
27 cl, 4 ex
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