METHOD OF TREATING NEUROLOGICAL DISORDERS WITH CARDIAC GLYCOSIDES Russian patent published in 2016 - IPC A61K36/24 A61P25/00 A61P25/28 

Abstract RU 2582223 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely to a method of treating a neurological disorder specified in Alzheimer disease, Huntington disease and cerebral accident. A method of treating a neurological disorder specified in Alzheimer disease, Huntington disease and cerebral accident in an individual involving: administering a composition containing a cardiac glycoside in an effective amount, wherein the cardiac glycoside is oleandrin as a part of an extract produced by supercritical fluid extraction from vegetable mass of oleander in CO2 or supercritical fluid extraction from vegetable mass of oleander in CO2 in the presence of a modifier specified in methanol, ethanol and propanol; the extract additionally contains one or more other therapeutically effective agents taken together with the cardiac glycoside in extraction, containing at least oleaside A, oleandrigenine, neritaloside and odoroside; the cardiac glycoside contains nerifoline. A method for improving the clinical status of a statistically significant number of individuals in the population of individuals with the neurological disorder. A method for reducing or preventing a higher frequency of neurological disorder development. A remote method of treating cerebral accident in the individual.

EFFECT: method is effective for treating the neurological disorder specified in Alzheimer disease, Huntington disease and cerebral accident.

28 cl, 7 dwg, 13 ex

Similar patents RU2582223C2

Title Year Author Number
METHOD OF TREATING NEUROLOGICAL CONDITIONS WITH CARDIAC GLYCOSIDS 2011
  • Eddington Otis S.
  • Nyuman Robert A.
RU2674679C2
METHOD OF TREATING NEUROLOGICAL CONDITIONS WITH EXTRACT OF NERIUM SPECIES OR THEVETIA SPECIES 2011
  • Eddington Otis K.
  • Nyuman Robert A.
RU2606594C2
METHOD AND IMPROVED NEUROPROTECTIVE COMPOSITION FOR TREATMENT OF NEUROLOGICAL PATHOLOGICAL CONDITIONS 2018
  • Newman, Robert, A.
  • Addington, Otis, C.
  • Lo, Donald, C.
  • Kaltenbach, Linda, S.
RU2758376C2
KIT FOR DETECTING PROBABILITY OF THERAPEUTIC RESPONSE TO ANTI-CANCER CHEMOTHERAPY WITH CARDIAC GLYCOSIDE 2008
  • N'Juman Robert A.
  • Jang Pejing
  • Ehddington O. Krehndell
RU2571687C2
METHOD FOR DETERMINING PROBABILITY OF THERAPEUTIC RESPONSE ON CANCER THERAPY WITH CARDIAC GLYCOSIDE 2008
  • N'Juman Robert A.
  • Jang Pejing
  • Ehddington O. Krehndell
RU2508114C2
SUPERCRITICAL LIQUID EXTRACT CONTAINING CARDIAC GLYCOSIDE 2006
  • Ehddington Krehndell
  • Chzhan Fyn
  • Kouleng Dzhon Dzh.
RU2398591C2
METHOD OF EXTRACTING CARDIAC GLYCOSIDES AND BASED ON THEM COMPOSITIONS 2009
  • Smozers Donal'D
RU2530654C2
PHARMACEUTICAL COMPOSITION FOR USE IN TREATMENT OF NEURODEGENERATIVE DISEASE 2012
  • Khess Zibille
  • Khelsher Kristian
  • Beme Andres
  • Menyu Agnes
  • Prade Loran
  • Topen Veronik
RU2618412C2
METHODS OF NEURAL DISORDER TREATMENT WITH USING HEMATOPOIETIC GROWTH FACTORS 2003
  • Shebitts Vol'F-Rjudiger
  • Shnajder Armin
  • Krjuger Karola
  • Zommer Klemens
  • Shvab Shtefan
  • Koll'Mar Rajner
  • Maurer Martin
  • Veber Daniehla
  • Gassler Nikolaus
RU2353385C2
AGONISTS OF ALPHA-2B OR 2B/2C ADRENORECEPTORS FOR NEURODEGENERATIVE DISEASES TREATMENT 2003
  • Viler Larri A.
  • Dzhil Dehniehl V.
  • Donello Dzhon E.
RU2330649C2

RU 2 582 223 C2

Authors

Eddington Otis S.

Njuman Robert A.

Dates

2016-04-20Published

2011-01-10Filed