FIELD: biotechnologies.
SUBSTANCE: invention relates to production of DAXX protein antiapoptotic fragments and can be used in medicine for treating acute myocardial infarction (AMI), cerebral infarction, during organ transplantation, operations on heart, acute blood circulation disorders, reperfusion injuries and ischaemia. Obtaining biologically active fragments form 17-24 sequential amino acids of DAXX protein including KKSRKEKKQTGSGPLG, as well as their peptide mimetics and conjugates with peptide penetrating into cells.
EFFECT: invention allows effective inhibition of cell apoptosis, in particular cell apoptosis mediated by Fas receptor.
22 cl, 17 dwg, 4 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| USE OF PEPTIDE FOR TREATMENT OF CARDIOVASCULAR DISEASES | 2013 |
|
RU2672341C2 |
| ALLOSTERIC ANTIBODIES AGAINST HUMAN HER3 NON COMPETITIVE FOR NEUREGULIN AND USE THEREOF | 2013 |
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| CELL-PENETRATING PEPTIDES AND THEREOF APPLICATION | 2011 |
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RU2556800C2 |
| MIMETIC PEPTIDES | 2013 |
|
RU2662973C2 |
| NOVEL CONSTRUCTIONS OF TRANSPORTERS AND CONJUGATE MOLUCELES WHICH ARE TRASPORTERS OF CARGO-MOLECULES | 2009 |
|
RU2570632C2 |
| COMPOSITION FOR TREATING ARTHRITIS | 2009 |
|
RU2563360C2 |
| SELECTIVE INHIBITORY PEPTIDES Nox-1 AND USE THEREOF | 2014 |
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RU2699726C2 |
| EFFECTIVE TRANSPORT INTO LEUKOCYTES | 2009 |
|
RU2558240C2 |
| METHODS FOR IDENTIFYING AND PREDICTING RISK OF CARDIOVASCULAR EVENT OR DISEASE OR FATAL OUTCOME, METHODS FOR ASSESSING SEVERITY AND MONITORING OF CARDIOVASCULAR EVENT OR DISEASE, METHOD FOR MONITORING EFFECTIVENESS OF THERAPY | 2014 |
|
RU2721690C2 |
| NOVEL CELL-PENETRATING PEPTIDES | 2013 |
|
RU2670488C2 |
