NON-COMPETITIVE NICOTINIC RECEPTOR ANTAGONISTS Russian patent published in 2016 - IPC C07C211/41 C07C211/38 C07D493/20 C07D491/22 A61K31/13 A61K31/34 A61P25/30 A61P25/26 A61P9/12 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to new compounds of formula I or their pharmaceutically acceptable salts possessing the properties of a neuronal nicotinic receptor antagonist. The compounds can find application for treating a disease or condition, which represents irritable bowel syndrome with diarrhoea (IBS-D), overactive bladder (OAB), nicotine addiction, smoking cessation, depression, major depressive disorder, or hypertension mediated by neuronal nicotinic receptor activity. In formula I: each of R¹ and R² individually represents H, C_1-6alkyl, or R¹ and R² are bound to a nitrogen atom to which they are attached, to form 3-8-merous ring; R³ represents H, C_1-6alkyl; each of R⁴, R⁵, R⁶ and R⁷ individually represents H, C_1-6alkyl; L¹ represents a linker specified in a group consisting of CR⁸R⁹, CR⁸R⁹CR¹⁰R¹¹ and O; L² represents a linker specified in a group consisting of CH₂, CH₂CH₂, CH₂CH₂CH₂ or CH₂CH₂CH₂CH₂; each of R⁸, R⁹, R¹⁰ and R¹¹ individually represents hydrogen or C_1-6alkyl, and a dashed line represents an optional double bond.

EFFECT: producing salts possessing the properties of the neuronal nicotinic receptor antagonist.

15 cl, 1 tbl, 9 ex