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2 448 969

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IPC

C07D487/08(2006-01-01)

A61K31/549(2006-01-01)

A61P25/00(2006-01-01)

A61P25/08(2006-01-01)

(21) (22)

Application

2009120674/04, 2007-11-01

(24)

Start date

2007-11-01

(22)

Actual filing date

2007-11-01

(45)

Published

2012-04-27

(72)

Inventor

Mazurov AnatolijMjao Lan'Sjao Jun'-DehKhehmmond Filip S.Miller Krehjg Kh.Akireddi Srinivisa RaoMerti V. SrinivasaUitaker Redzhina S.Brejning Skott R.Melvin Mehtt S.

(73)

Holder

Targasept, Ink.

AMIDES OF DIAZABICYCLOALKANES, SELECTIVE WITH RESPECT TO ACETYLCHOLINE SUBTYPE OF NICOTINE RECEPTORS AND PHARMACEUTIC COMPOSITION AND METHODS OF TREATMENT WITH THEIR APPLICATION Russian patent published in 2012 - IPC C07D487/08 A61K31/549 A61P25/00 A61P25/08

Abstract RU 2448969 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to novel compound, namely to N-(5-chlorfuran-2-ylcarbonyl)-3,7-diazabicyclo[3.3.0]octane or its pharmaceutically acceptable salts, pharmaceutical compositions for treatment of conditions and disorders associated with dysfunction of central nervous system, containing said compound, as well as methods of treatment. Claimed compound demonstrates selectivity with respect to neuron nicotine receptors of subtype α4β2 in central nervous system (CNS) and bind with them with high affinity.

EFFECT: compound and compositions based on it can be applied for treatment and/or prevention of wide spectrum of diseases and disorders, in particular, CNS disorders.

6 cl, 1 tbl, 11 ex

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RU 2 448 969 C2

Authors

Mazurov Anatolij

Mjao Lan'

Sjao Jun'-Deh

Khehmmond Filip S.

Miller Krehjg Kh.

Akireddi Srinivisa Rao

Merti V. Srinivasa

Uitaker Redzhina S.

Brejning Skott R.

Melvin Mehtt S.

Dates

2012-04-27—Published

2007-11-01—Filed