COMPOSITE COLLAGEN SPONGE AND METHOD OF MAKING SAME Russian patent published in 2016 - IPC A61L15/32 A61L15/44 A61K38/18 A61K47/12 A61K47/26 A61K47/42 

FIELD: medicine.

SUBSTANCE: invention relates to medicine. Composite collagen sponge is intended for bleeding control, as well as for stimulation of growth and cell proliferation. Sponge comprises collagen, cell growth factors, and a protecting agent in an amount of 10-50 wt%, where protective agent contains amino acids, saccharides and albumin in weight ratio of 1-11:1.25-17.5:1-7.5. Method of producing sponge involves a step for virus inactivation, which includes two steps: first step is a viral inactivation organic solvent/detergent; second step is 30-120-minute solution treatment sponge on a water bath at 90-100 °C, and is carried out in presence of a protective agent. Sponge may be subjected to viral inactivation for a long time at high temperature, while bioactivity of collagen and growth factors is maintained.

EFFECT: technical result consists in that sponge has water-absorbing capacity of more than 52 times based on weight of sponge and has modulus of elasticity greater than 70 N/cm².

7 cl, 3 ex, 11 tbl, 3 dwg