METHOD FOR PRODUCING CARRIER PARTICLES FOR DRY POWDERS FOR INHALATIONS Russian patent published in 2016 - IPC A61K9/14 A61K9/72 A61K47/26 A61K47/12 A61K31/00 A61M15/00 A61J3/02 

FIELD: medicine.

SUBSTANCE: described are carrier particles, a method for producing a carrier for a dry power pharmaceutical composition for inhalations, as well as the pharmaceutical composition in the form of a dry powder for inhalations. The active composition contains an active ingredient and carrier particles. The above carrier particles represent an alpha-lactose monohydrate with the mass diameter from 900 to 400 microns and are magnesium stearate-coated. The carrier particles are prepared by the method according to which the coating is deposited by a dry process in a mixer granulator with a high shear force at a rotational speed of 500 to 1,500 rpm.

EFFECT: composition homogeneity in the environment comparable to that may occur when in use, the stronger adhesion of magnesium stearate to the particle carrier surface during inhalation, and therefore not suitable for systemic absorption that further increases the powder safety.

13 cl, 13 tbl, 8 ex, 3 dwg