INHALATION PARTICLES CONTAINING COMBINATION OF ANTICHOLINERGIC, CORTICOSTEROID AND BETA-ADRENERGIC AGENTS Russian patent published in 2019 - IPC A61K31/573 A61K31/167 A61K31/40 A61K47/00 A61K9/12 A61K9/14 A61K9/72 A61M15/00 A61P11/00 

FIELD: chemistry; medicine.

SUBSTANCE: present invention relates to multicomponent microparticles for use in a composition for preventing and/or treating inflammatory or obstructive respiratory diseases. Each microparticle contains a combination of beclomethasone dipropionate, formoterol fumarate and glycopyrronium bromide as active ingredients at ratio of 35:10:55 to 94:1:5 by weight. Method of producing said microparticles involves preparing a solution of three said active components in a solvent consisting of a mixture of ethanol and water in ratio of 85:15 to 95:5 by volume, forming an aerosol from the obtained solution and drying the sprayed droplets to form microparticles. Obtained microparticles are characterized by a shape factor from 0.95 to 1.05. Also described are a pharmaceutical aerosol composition for metered dose inhalers containing said microparticles in a suspension in a liquefied propellant gas, and a dry powder composition containing said microparticles and a carrier which is an alpha-lactose monohydrate in combination with magnesium stearate. Also described are a metered inhaler under pressure and a dry powder inhaler containing said pharmaceutical composition.

EFFECT: microparticles according to the invention are characterized by homogeneous morphology and are stable for a long period of time.

12 cl, 1 dwg, 7 tbl, 4 ex