FIELD: medicine.
SUBSTANCE: invention relates to aggregated particles for inhalation containing nanodispersed particles of the medicament of skipidium bromide, vilanterol trifenatate and fluticasone furoate. Aggregated particles of the invention have a mass median aerodynamic diameter of less than 100 mcm. Aggregated particles may also contain nanoparticulate excipient particles and one or more binders. Invention also relates to a powder composition suitable for inhalation which comprises said aggregated particles, to a method for producing said aggregated particles and to a product for use in the treatment of a respiratory disease, such as asthma or COPD. Product of the invention is a dry powder inhaler or metered dose inhaler containing said aggregated particles or said powder composition.
EFFECT: aggregated particles of the invention are characterized by improved chemical stability and satisfactory aerodynamic characteristics.
16 cl, 16 dwg, 15 tbl, 7 ex
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