FIELD: pharmaceuticals.
SUBSTANCE: invention relates to the field of medicinal compounds. Proposed is pyruvate-amide compounds of formula (X), which inhibit the allergen is dust mite group 1, which is a peptidase, e.g., Der p 1, Der f 1, Eur m 1.
EFFECT: also provided are pharmaceutical compositions comprising said compounds and use of said compounds and compositions for inhibiting allergen 1 group is a peptidase dust mites, and for the treatment of diseases and disorders mediated by allergen dust mite group 1, in particular asthma, rhinitis, allergic conjunctivitis, atopic dermatitis, allergic condition caused by dust mite allergic condition caused by dust mite allergen group 1 and atopy in dogs.
51 cl, 3 dwg, 1 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PYRROLIDINE-2-ONES AS INHIBITORS OF XA FACTOR | 2002 |
|
RU2318807C2 |
| IMIDAZOPYRAZINES AS TYROSINE KINASE INHIBITORS | 2004 |
|
RU2405784C2 |
| NEW SUBSTITUTED AZAINDOLINE DERIVATIVES AS NIK INHIBITORS | 2018 |
|
RU2780577C2 |
| A-EXO-AZASPIRO-INHIBITORS OF THE MENIN-MLL INTERACTION | 2018 |
|
RU2795096C2 |
| MACROHETEROCYCLIC COMPOUNDS | 2001 |
|
RU2275373C2 |
| NEW QUINOLINE COMPOUNDS | 2018 |
|
RU2810113C2 |
| N-CONTAINING HETEROARYL DERIVATIVES AS JAK3 KINASE INHIBITORS | 2010 |
|
RU2553681C2 |
| HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS | 2010 |
|
RU2615130C2 |
| BICYCLIC HETEROARYL DERIVATIVES AS CFTR STIMULATORS | 2017 |
|
RU2753056C2 |
| 3-ARYL-5-SUBSTITUTED ISOQUINOLIN-1-ONE COMPOUNDS AND THEIR THERAPEUTIC APPLICATION | 2013 |
|
RU2696572C2 |
