BICYCLIC HETEROARYL DERIVATIVES AS CFTR STIMULATORS Russian patent published in 2021 - IPC C07D487/04 A61K31/519 A61K31/53 A61P11/00 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a compound of formula I or to its pharmaceutically acceptable salt. In formula I, Y is a five-element heteroaryl containing 2-3 heteroatoms, each of which is independently selected from a group consisting of N; Z is a phenyl, optionally substituted with 1 or 2 halogens; each R^1a and R^1b is independently selected from a group consisting of H, C₁-C₆ alkyl. The invention also relates to the compound of formula II, to the compound of formula III, and to individual compounds.

EFFECT: technical result is that new compounds are obtained as a stimulator of the cystic fibrosis transmembrane conductance regulator (CFTR).

21 cl, 99 ex