FIELD: biology.
SUBSTANCE: invention relates to microbiology and molecular genetics. Disclosed is a complex of recombinant polypeptides for prevention and treatment of bacterial infections caused by Streptococcus agalactiae and/or Streptococcus pyogenes. Complex comprises in equal portions recombinant polypeptides P6, recScaAB, StV, RV1 and Csp1a having amino acid sequence SEQ ID No: 1-5, respectively. Complex has no toxic action on body in mammals. Causes a synergetic effect during synthesis of specific antibodies anti-P6, anti-recScaAB, anti-StV, anti-PB1 and anti-Csp1a, which have protective action against Streptococcus agalactiae and Streptococcus pyogenes, shows a synergetic effect in relation to Streptococcus agalactiae.
EFFECT: prevention and treatment of bacterial infections caused by Streptococcus agalactiae and/or Streptococcus pyogenes.
1 cl, 5 tbl, 19 ex, 21 dwg
Title | Year | Author | Number |
---|---|---|---|
RECOMBINANT DNA ENSURING PRODUCTION OF RECOMBINANT PROTEIN PBI EXPRESSING PROTECTIVE PROPERTIES IN RELATION TO STREPTOCOCCUS PYOGENES AND STREPTOCOCCUS AGALACTIAE | 2008 |
|
RU2378374C2 |
RECOMBINANT POLYPEPTIDE StV POSSESSING PROTECTIVE PROPERTIES IN RELATION TO Streptococcus agalactiae, RECOMBINANT DNA StV, ITS CODING AND RECOMBINANT STRAIN Escherichia coli M15-StV CONTAINING RECOMBINANT PLASMID PQE-StV | 2012 |
|
RU2542483C2 |
METHOD FOR INTROGRESSION OF PATHOGENIC STREPTOCOCCUS GENES IN CHROMOSOMAL DNA OF PROBIOTIC STRAIN OF ENTEROCOCCUS FAECIUM L3 FOR EXPRESSION IN PILES | 2015 |
|
RU2640250C2 |
RECOMBINANT DNA PROVIDING PRODUCTION OF POLYPEPTIDES P6, P7, P8 EXHIBITING PROTECTIVE PROPERTIES AGAINST STREPTOCOCCUS AGALACTIAE AND SELECTIVELY CONNECTING IgA | 2008 |
|
RU2387715C2 |
CHIMERIC RECOMBINANT PROTEIN, HAVING PROTECTIVE PROPERTIES AGAINST STREPTOCOCCUS PYOGENES | 2016 |
|
RU2685957C2 |
LIVE VACCINE BASED ON ENTEROCOCCUS FAECIUM L3 PROBIOTIC STRAIN FOR PREVENTION OF INFECTION CAUSED BY STREPTOCOCCUS PNEUMONIE | 2018 |
|
RU2701733C1 |
VACCINE CAPABLE TO MAKE IMMUNITY IN HOST AGAINST INFECTION CAUSED BY STREPTOCOCCUS GROUP B, METHOD OF PREVENTION OF INFECTION CAUSED BY STREPTOCOCCUS GROUP B AND A METHOD OF ATTENUATION OF INFECTION CAUSED BY STREPTOCOCCUS GROUP B | 1990 |
|
RU2113234C1 |
METHOD FOR CREATING RECOMBINANT ENTEROCOCCUS L3-SARSN1 STRAIN BASED ON BIOLOGICALLY ACTIVE ENTEROCOCCUS FAECIUM L3 STRAIN | 2022 |
|
RU2820058C1 |
INFLUENZA VIRUS STRAIN INFLUBACT-H7/PSPA FOR THE PRODUCTION OF A COMBINED VACCINE AGAINST INFLUENZA A VIRUS AND BACTERIAL PNEUMONIA CAUSED BY STREPTOCOCCUS PNEUMONIAE | 2021 |
|
RU2776196C1 |
RECOMBINANT SWINE INFLUENZA VIRUS H1N1 VACCINE AND METHOD FOR PREPARING IT | 2010 |
|
RU2451027C2 |
Authors
Dates
2016-06-20—Published
2014-08-11—Filed