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2 685 957

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IPC

C07K14/315(2006-01-01)

C07K14/255(2006-01-01)

C07K19/00(2006-01-01)

(21) (22)

Application

2016152455, 2016-12-28

(24)

Start date

2016-12-28

(22)

Actual filing date

2016-12-28

(45)

Published

2019-04-23

(72)

Inventor

Suvorov Aleksandr NikolaevichDukhovlinov Ilya VladimirovichLeonteva Galina FedorovnaGrabovskaya Korneliya BorisovnaDuplik Nadezhda VladlenovnaKramskaya Tatyana AnatolevnaShevchenko Viktoriya Yurevna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Nauchnoe Uchrezhdenie Eksperimentalnoj Meditsiny"

CHIMERIC RECOMBINANT PROTEIN, HAVING PROTECTIVE PROPERTIES AGAINST STREPTOCOCCUS PYOGENES Russian patent published in 2019 - IPC C07K14/315 C07K14/255 C07K19/00

Abstract RU 2685957 C2

FIELD: biotechnology.

SUBSTANCE: invention refers to biotechnology, microbiology and molecular genetics. Disclosed is a chimeric recombinant protein consisting of conservative and immunogenic fragments of amino acid sequences of surface proteins Streptococcus pyogenes: Sic, SpySEP, SpeA, ScpA, ScaAB and terminal domains of flagellin Salmonella typhiurium FliA and FliC, which serve as internal adjuvant. Declared protein induces in vivo synthesis of class G antibodies specific to said chimeric protein and having protective properties with respect to Streptococcus pyogenes.

EFFECT: invention can be used in medical industry when producing Streptococcus pyogenes group A streptococcus vaccines (SGA).

1 cl, 2 dwg, 3 ex

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RU 2 685 957 C2

Authors

Suvorov Aleksandr Nikolaevich

Dukhovlinov Ilya Vladimirovich

Leonteva Galina Fedorovna

Grabovskaya Korneliya Borisovna

Duplik Nadezhda Vladlenovna

Kramskaya Tatyana Anatolevna

Shevchenko Viktoriya Yurevna

Dates

2019-04-23—Published

2016-12-28—Filed