SUPRAMOLECULAR COMPLEX WITH NICLOSAMIDE AND PREPARATION METHOD THEREOF Russian patent published in 2016 - IPC A61K31/609 A61K47/30 A61P33/10 

FIELD: veterinary science.

SUBSTANCE: invention can be used for treating cestodaria in animals. Said technical result is achieved by proposed composition of supramolecular complex of niclosamide with vinyl pyrrolidone polymer at ratio of 1:5 by weight and disclosed production method which consists in combined mechanochemical treatment in roller ball mill with addition of 700 g of metal balls within 2 hours during drum rotation at speed of 90 rpm to produce supramolecular complex with particles size up to 10 microns.

EFFECT: invention is aimed at higher water solubility, bioavailability and anthelmintic effect of niclosamide when lowering dose by more than 10 times after mechanochemical treatment of niclosamide and vinyl pyrrolidone polymer substance in ball mill of impact-abrasive type.

1 cl, 6 ex, 3 tbl