SUBSTITUTED [1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-7-YL COMPOUNDS AS THE INHIBITORS OF PDE2 Russian patent published in 2018 - IPC C07D487/04 A61K31/519 A61P25/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I) or pharmaceutically acceptable salts thereof , in which X is -CH₂- or -O-; Y is -CH₂- or -CF₂-; Z is -CH₂- or -C(=O)-; R¹ is a member selected from the group consisting of: (a) phenyl unsubstituted or substituted by one, two or three members of R^a; (b) a 5-6 membered monocyclic heteroaromatic ring having one or two heteroatoms independently selected from N, S, O, or a 8–10 membered bicyclic heteroaromatic ring, having one, two or three heteroatoms independently selected from N, S, O, each of which is unsubstituted or substituted by one, two, or three members of R^c; and (c) a 9-10 membered partially unsaturated heterocycloalkyl ring having one or two heteroatoms selected from O, wherein said ring is unsubstituted or substituted with one or more -F or -OCH₃; and R² is -C_1–6alkyl; values of other radicals are given in the patent claim. Invention also relates to individual compounds selected from the group, pharmaceutical compositions, and a method of treating a neurological disorder.

EFFECT: new compounds of formula (I) having the properties of PDE2 inhibitors have been obtained.

31 cl, 1 tbl, 568 ex