NITROGEN-CONTAINING HETEROARYL DERIVATIVES Russian patent published in 2009 - IPC C07D235/18 C07D403/12 A61K31/4184 A61P31/12 

FIELD: medicine.

SUBSTANCE: in new compounds of formula (I): R¹ is specified from the group including -OR⁷ and -NR⁸R⁹; where R⁷ means hydrogen; R⁸ and R⁹ are independently chosen from the group including hydrogen, aryl, substituted aryl containing one to three substitutes, preferentially one to two substitutes independently chosen from the group including alkenyl, substituted alkenyl containing one to three, preferentially one to two substitutes independently chosen from the group including carboxyl and carboxyl esters; R² and R¹² are independently chosen from the group including hydrogen, alkyl and alkyl substituted with 5-hydroxy-indolyl group; or R² and R¹² together with carbon atom whereto attached, form cycloalkyl group; R³ means hydrogen; each R⁴ independently means halogen; Q means oxygen; X means oxygen; R⁵ means alkylene; R⁶ is specified from the group consisting of substituted aryl containing one to three, preferentially one to two substitutes independently chosen from group consisting of acylamino, aryl, substituted aryl, containing one to three, preferentially from one to two substitutes chosen from halogen; and n is equal 0 to 3; or to its pharmaceutically acceptable salts. Besides the invention concerns a pharmaceutical composition, to the method of treatment or prevention of virus infections in mammals.

EFFECT: production of the new biologically active compound active with respect to treatment of virus infections in mammals, partially mediated with a member of flaviviridae virus family.

12 cl, 5 ex