COMBINATION OF AURORA KINASE INHIBITORS AND ANTI-CD20 ANTIBODIES Russian patent published in 2014 - IPC A61K31/4745 A61K31/55 A61K39/395 A61P35/00 

Abstract RU 2535032 C2

FIELD: medicine.

SUBSTANCE: invention relates to medicine and represents a method of treating hematologic malignant diseases, which includes the introduction to a subject of a therapeutically effective quantity of an Aurora kinase inhibitor simultaneously or successively with an anti-CD20 antibody, where the Aurora kinase inhibitor represents 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido [5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoic acid or its pharmaceutically acceptable salt and where the anti-CD20 antibody represents rituximab.

EFFECT: invention provides more efficient treatment in comparison with monotherapy.

8 cl, 4 ex, 27 tbl

Similar patents RU2535032C2

Title Year Author Number
TRICYCLIC DERIVATIVES, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND METHOD OF INHIBITION OF VASOPRESSINE 1994
  • Dzhej D. Olbrajt
  • Mehrvin F. Rejch
  • Fuk-Vakh Sam
  • Ksjumej Du
RU2149160C1
METHOD OF PRODUCING PYRIMIDO-2-BENZASIPINES OR THEIR PHARMACEUTICALLY COMPATIBLE ACID-ADDITIVE SALTS (VERSIONS) 0
  • Rodnej Jan Frajer
  • Normen Vashbern Gilmen
  • Ojgen Dzhon Tribulski
  • Armin Valzer
SU1181547A3
CONDENSED AZEPINE DERIVATIVES AS ANTIDIUTETIC AGENTS 2001
  • Ehshuehrt Dorin Mehri
  • Pitt Gari Robert Uil'Jam
  • Khadson Piter
  • Jej Kristofer Martin
  • Franklin Richard Dzheremi
  • Sempl Grem
  • Dzhenkins Dehvid Pol
RU2269517C2
(3-CYCLOALKYL-2, 3, 4, 5 - TETRAHYDRO-1H-BENZO [d] AZEPIN-7-YLOXY) DERIVATIVES, USE THEREOF FOR INHIBITING H3 RECEPTORS, PHARMACEUTICAL COMPOSITION AND PREPARATION METHOD 2003
  • Bamford Mark Dzhejms
  • Din Dehvid Kennet
  • Sekhmi Sandzhit Singkh
  • Uilson Dehvid Mehtt'Ju
  • Vizerington Dzhejson
RU2388752C2
2-PHENYLAMINOPYRIMIDINE DERIVATIVES AS LEUCINE-RICH REPEAT KINASE 2 (LRRK2) MODULATORS FOR TREATMENT OF PARKINSON'S DISEASE 2012
  • Bejker-Glenn Charlz
  • Berdik Daniel Dzhon
  • Chembers Mark
  • Chan Brajan K.
  • Chen Khuejfen
  • Estrada Entoni
  • Ganzner-Toste Dzhanet
  • Shor Daniel
  • Svini Zakari
  • Van Shumej
  • Chzhao Gujlin
RU2661197C2
SELECTIVE HISTAMINE H4 RECEPTOR ANTAGONISTS FOR TREATING VESTIBULAR DISORDERS 2009
  • Desmadril Zhil
  • Shaber Kristyan
RU2589846C2
ANTIVIRAL REMEDIES FOR TREATMENT AND PREVENTION OF HIV INFECTION 2021
  • Kurkin Aleksandr Vitalevich
  • Manasova Ekaterina Vladimirovna
  • Kazyulkin Denis Nikolaevich
  • Ivanov Vladimir Nikolaevich
  • Shurygin Mikhail Gennadevich
RU2780103C1
ANTIVIRAL REMEDIES FOR TREATMENT AND PREVENTION OF HIV INFECTION 2020
  • Kurkin Aleksandr Vitalevich
  • Manasova Ekaterina Vladimirovna
  • Kazyulkin Denis Nikolaevich
  • Ivanov Vladimir Nikolaevich
  • Shurygin Mikhail Gennadevich
RU2780101C2
PYRAZOLE DERIVATIVES APPLIED AS PROTEIN KINASE INHIBITORS 2013
  • Khollik Dzhonatan Dzhejms
  • Dzhouns Styuart Donald
  • Flinn Kler Dzhun
  • Tomas Majkl Dzhordzh
RU2623221C2
IMIDAZO[1,5-a]PYRIMIDO[5,4-d][1]BENZAZEPINE DERIVATIVES AS MODULATORS OF GABA A RECEPTOR 2002
  • Mashiadri Raffaehllo
  • Tomas Ehndr'Ju Uill'Jam
  • Vikhmann Jurgen
RU2287531C2

RU 2 535 032 C2

Authors

Manfredi Mark

Dates

2014-12-10Published

2009-12-15Filed