FIELD: chemistry.
SUBSTANCE: invention relates to chemical-pharmaceutical industry and concerns anticatarrhal preparation in form of capsules filled with micro tablets, and method for preparing it. Method of producing includes mixing of paracetamol, amantadine hydrochloride, caffeine, Bovis calculus artifactus, Chlorpheniramine maleate for 10-15 minutes, powder mixture is passed through sieve with size of 80 mesh and then once more mixed for 10-15 minutes, obtained mixture is sprayed with paste-like mass of hypromellose, prepared by adding purified water to hypromellose at 80 °C, stirring till homogeneous state and holding for 20-25 minutes, coated with hypromellose micro tablets are passed through sieves with size of 14-18 mesh, dried for 55-65 minutes at 40-50 °C and polished with subsequent filling of capsules with mixture of obtained micro tablets.
EFFECT: invention provides minimisation of auxiliary substances, simplified production steps (there is no need in separate micronising and pelitizing of each component), high stability of active substances during storage, reduced side effects as dry mucous and sleepiness.
2 cl, 4 ex, 3 tbl
