FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing exo- and endo- isomers of 2-(6′-chloropyridine-3′-yl) -7-azabicyclo [2.2.1] heptane - non-opioid action analgesics. Disclosed is a method based on cyclisation of the corresponding substituted cyclohexylamine (formula III and formula IV) in low-molecular alcohol solution in the presence of sterically hindered tertiary amine.
EFFECT: proposed method is easily implemented in industrial conditions and enables to obtain endo- and exo- isomers of 2-(6′-chloropyridine-3′-yl) -7-azabicyclo [2.2.1] heptane with high yield and high degree of purity.
9 cl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING 2-EXO-[3'-(6'-CHLOROPYRIDYL)]-7-AZABICYCLO[2,2,1]-HEPTANE | 2013 |
|
RU2537390C1 |
| METHOD FOR PREDICTING THE THERAPEUTIC EFFECT OF AN LSD 1INHIBITOR BASED ON THE INSM1 EXPRESSION | 2018 |
|
RU2789449C2 |
| ANTITUMOR EFFECT ENHANCER USING NEW BIPHENYL COMPOUND | 2018 |
|
RU2765153C2 |
| NEW BIPHENYL COMPOUND OR ITS SALT | 2018 |
|
RU2765152C2 |
| DIPEPTIDYL PEPTIDASE-4 INHIBITOR FOR TREATING TYPE 2 DIABETES MELLITUS, COMPOUNDS (VERSIONS) | 2018 |
|
RU2712097C1 |
| AZABICYCLIC ALKANE DERIVATIVES SUBSTITUTED WITH CONDENSED BICYCLOHETEROCYCLE | 2007 |
|
RU2437884C2 |
| NEW BIPHENYL COMPOUND OR ITS SALT | 2016 |
|
RU2726622C2 |
| O-ACYLAMIDOXIMES AND 1,2,4-OXADIAZOLES CONTAINING A FRAGMENT OF BICYCLO[2.2.1]HEPTANONE-2 AS INHIBITORS OF THE REPRODUCTION OF PHYLOGENETICALLY DIFFERENT INFLUENZA A VIRUSES: STRAINS A/PUERTO RICO/8/34 (H1N1), A/ANHUI/1/2013 (H7N9) | 2022 |
|
RU2798171C1 |
| 2-OXA-5-AZABICYCLO[2.2.1]HEPTANE-3-YL DERIVATIVES | 2015 |
|
RU2697651C2 |
| METHOD FOR PREPARING AMIDES OF THE SERIES OF 1,4,7,7-TETRAMETHYLBICYCLO-[2,2,1]-HEPTANE | 0 |
|
SU1631058A1 |
