INDASOLE INHIBITORS OF Wnt SIGNAL PATH AND THEIR THERAPEUTIC APPLICATIONS Russian patent published in 2017 - IPC C07D471/04 A61K31/437 A61K31/444 A61K31/4545 A61K31/496 A61K31/5377 A61P19/00 A61P31/10 A61P31/12 A61P25/28 A61P11/00 A61P35/00 

Abstract RU 2638932 C2

FIELD: medicine.

SUBSTANCE: invention relates to a indasole derivative that has the following formula , or its pharmaceutically acceptable salt, as well as a pharmaceutical composition containing it. The invention relates to methods for treatment of disorders characterized by the activation of Wnt-signalling pathways (e.g., cancer, abnormal cell proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), including introduction of a therapeutically effective amount of this compound or pharmaceutically acceptable salt thereof. This compound can also be used in modulation of cellular events, mediated by Wnt-signalling, as well as for treatment of genetic diseases and neurological conditions/disorders/diseases due to mutations or disregulation of the Wnt pathway and/or one or more components of Wnt-signalling.

EFFECT: inhibits the Wnt signalling pathway and can be used to treat various diseases and pathologies.

28 cl, 8 tbl, 8 ex

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RU 2 638 932 C2

Authors

Khud Dzhon

Uollejs Devid Mark

Ks Sunil Kumar

Dates

2017-12-19Published

2013-03-13Filed