INDAZOLIE WNT SIGNAL PATHWAY INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS Russian patent published in 2019 - IPC C07D471/04 A61K31/437 A61K31/444 A61P3/10 A61P11/00 A61P19/00 A61P25/28 A61P31/10 A61P31/12 A61P35/00 A61P43/00 

Abstract RU 2682245 C1

FIELD: chemistry.

SUBSTANCE: invention relates to indazole derivatives having a structure of the formula I, or to its pharmaceutically acceptable salts, in which R1 and R2 have the meaning given in the claims. Methods for treating Wnt-related disease states are also described.

.

EFFECT: claimed indazole derivatives may find use in the treatment of disorders characterized by activation of the Wnt-signaling pathway (for example, cancer, abnormal cell proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), when modulating cellular events mediated by Wnt-signaling, as well as treating genetic diseases and neurological conditions, disorders or diseases mediated by mutation or disregulation of the Wnt pathway and/or one or more components of Wnt signaling.

34 cl, 8 tbl, 8 ex

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RU 2 682 245 C1

Authors

Hood, John

Wallace, David, Mark

Kc, Sunil, Kumar

Dates

2019-03-18Published

2017-12-12Filed