DIKETONES AND HYDROXYKETONES AS ACTIVATORS OF CATENIN SIGNALLING PATHWAY Russian patent published in 2016 - IPC C07D319/16 C07D407/06 C07D417/06 C07D405/06 C07D213/30 A61K31/12 A61K31/36 A61P17/00 A61P17/10 A61P35/00 

FIELD: pharmaceutics.

SUBSTANCE: present invention relates to compounds or pharmaceutically acceptable salts thereof of general formula I, where R¹ is ; R² is selected from a group consisting of substituted or unsubstituted phenyl and , and ; and R³, R⁴, R⁵ and R⁶ all denote H, as well as to compounds II and III.

EFFECT: invention also relates to pharmaceutical compositions based on said compounds, method of activating a Wnt signal transmission, methods of treating diseases associated with signal transduction, and use thereof for treating such diseases as osteoporosis and osteoarthropathy; imperfect osteogenesis, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, head face defects, oncolytic bone disease, traumatic brain injury, relating to differentiation and developing central nervous system, including Parkinson's disease, stroke, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; eye diseases, such as age-related macular degeneration, diabetic macular oedema or pigment pigmentosa and disease related to differentiation and growth of stem cells, including hair loss, disease related to hematopoiesis, and diseases associated with tissue regeneration.

39 cl, 2 tbl, 5 ex