FIELD: medicine; oncology.
SUBSTANCE: present group of inventions refers to cancer treatment. For this purpose, a combination of drugs is introduced, including (6S,9aS)-N-benzyl-8-((6-(3-(4-ethylpiperazin-1-yl)azetidin-1-yl)pyridin-2-yl)methyl)-6-((2-fluorine-4-hydroxyphenyl)methyl)-4,7-dioxo-2-(prop-2-en-1-yl)-octahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide and anti-PD-1 antibody.
EFFECT: introduction of such combination provides effective cancer treatment, including in patients with low sensitivity to monotherapy with an immune control point inhibitor.
2 cl, 5 dwg, 1 tbl, 4 ex
| Title |
Year |
Author |
Number |
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|
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|
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2016 |
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|
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|
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|
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| CRYSTAL (6S,9AS)-N-BENZYL-8-({6-[3-(4-ETHYLPIPERAZIN-1-YL)AZETIDIN-1-YL]PYRIDIN-2-YL}METHYL)-6-(2-FLUORINE-4-HYDROXYBENZYL)-4,7-DIOXO-2-(PROP-2-EN-1-YL)HEXAHYDRO-2H-PYRAZINO[2,1-C][1,2,4]TRIAZINE-1(6H)-CARBOXAMIDE |
2016 |
|
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2017 |
|
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2017 |
|
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| REDUCTION OF TUMOR MASS BY INJECTING CCR1 ANTAGONISTS IN COMBINATION WITH PD-1 INHIBITORS OR PD-L1 INHIBITORS |
2017 |
- Sharo Izrael
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- Shall Tomas Dzh.
- Chzhan Penli
|
RU2745195C2 |
