METHOD OF PRODUCING STABLE SOFT GEL CAPSULE CONTAINING MICRO-ENCAPSULATED PROBIOTIC BACTERIA Russian patent published in 2016 - IPC A61K9/48 A61K9/50 A61K35/74 A61P1/00 B01J13/02 

FIELD: medicine.

SUBSTANCE: group of inventions relates to production of soft gel capsule containing micro-encapsulated probiotic bacteria, envisaging following steps: (a) providing microencapsulated probiotic bacteria with at least one coating containing at least one vegetable lipid, having a melting point from 35 °C to 75 °C; (b) suspending said microencapsulated probiotic bacteria in suspending preparation to produce filler; (c) mixing said aggregate with intensity less than approximately 3,000 rpm and temperature of approximately 15-32 °C to produce mixed filler; (d) reduction of agglomerates microencapsulated probiotic bacteria in mixed filler to produce deagglomerated filler; and (e) encapsulation deagglomerated aggregate in soft gel capsule, where is maintained integrity coating microencapsulated probiotic bacteria, as well as probiotic soft gel capsule, made in compliance with this method.

EFFECT: invention provides higher viability and stability of probiotic bacteria in soft gel capsule at prolonged storage during at least 24 months at room temperature.

18 cl, 4 ex, 10 tbl