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2 594 154

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(51)

IPC

C07D413/12(2006-01-01)

A61K31/553(2006-01-01)

A61P3/00(2006-01-01)

(21) (22)

Application

2014145115/04, 2014-11-10

(24)

Start date

2014-11-10

(22)

Actual filing date

2014-11-10

(45)

Published

2016-08-10

(72)

Inventor

Leonov Sergej ViktorovichMarusich Elena Ivanovna

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Fiziko-Tekhnicheskij Institut Universitet)"

CRYSTALLINE FORM OF METHYL ESTER 3-(N-P-TOLYLACETAMIDO) METHYL)-2,3,4,5-TETRAHYDROBENZO[f][1,4]OXAZEPINE-4-CARBOXAMIDE)THIOPHENE-2-CARBOXYLIC ACID, ACTIVE COMPONENT, PHARMACEUTICAL COMPOSITION AND DRUG Russian patent published in 2016 - IPC C07D413/12 A61K31/553 A61P3/00

Abstract RU 2594154 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a crystalline form of methyl ester 3-(7-((N-n-tolylacetamido)methyl)-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine-4-carboxamide)thiophene-2-carboxylic acid of formula 1, having receptor TGR5 agonist properties, as well as active component, pharmaceutical compositions and medicinal agents based thereon, which stimulate endocrine hormones secretion, for preventing and treating the diseases associated with glucose metabolism.

EFFECT: higher rate of dissolution and high storage stability as compared to the amorphous form.

4 cl, 2 tbl, 2 dwg, 7 ex

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RU 2 594 154 C2

Authors

Leonov Sergej Viktorovich

Marusich Elena Ivanovna

Dates

2016-08-10—Published

2014-11-10—Filed