METHOD OF GENERAL CONTROLLED HUMAN BODY HYPERTHERMIA Russian patent published in 2016 - IPC A61F7/00 A61H33/00 A61M16/01 A61K38/08 A61P43/00 A61B5/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to anaesthesiology and resuscitation, and can be used for general controlled hyperthermia of human organism. This is ensured by planned infusion preparation. Before immersing the patient in hot water 1 mg/ml of Dalargin is administered intravenously. Then patient's body is totally heated up by immersion, except the head, in hot water with temperature of 42-47 °C at the rate of body heating equal to 0.5-1.5 °C for 5 minutes with saturation within normal limits up to temperature increase in esophagus till 42.5-44 °C. Temperature is measured in the middle one-third part of oesophagus. Additionally temperature is measured on the eardrum. Besides, anaesthesiology protection is provided by introducing relaxing agents, anesthetics and hypnotic drugs. Hyperthermia is carried out with monitoring of pulse frequency, heart, blood pressure values, saturation. BIS-monitoring is carried out. According to BIS-monitoring with simultaneous reduction of heating rate a biological critical point is determined. During hyperthermia Dalargin is introduced in the above dose at each degree starting from 40 °C being measured in esophagus, as well as at biological critical point. For 5-20 minutes effective warming is maintained not extending beyond the biological critical point. Pathogenetically substantiated drugs are administered depending on the available pathology. Then the patient is removed from the bath and normal temperature is restored.

EFFECT: method provides higher clinical effectiveness due to selection of reliable criteria reaching maximum heating, establishing exposure time and peak hyperthermia, as well as a result of administration of drug preventing possible development of thermal shock.

1 cl, 1 ex