SUBSTITUTED 2-OXY-QUINOLINE-3-CARBOXAMIDES AS KCNQ2/3 MODULATORS Russian patent published in 2016 - IPC C07D215/54 C07D409/12 A61K31/47 A61K31/4709 A61P25/08 A61P25/18 A61P25/28 A61P29/00 

FIELD: chemistry.

SUBSTANCE: invention relates to substituted 2-oxy-quinoline-3-carboxamides of general formula (I) in form of free compounds or salts of physiologically acceptable acids or bases, where R¹ is C_1-6-aliphatic residue; 6-member unsubstituted or mono- or disubstituted aryl or unsubstituted 5-member heteroaryl, selected from a thienyl; R² is CF₃; C_1-4-aliphatic residue; O-C_1-4-aliphatic residue; R³, R⁴, R⁵ and R⁶ each independently represent H; F; Cl; Br; I; CN; CF₃; R⁷ is C_1-6-aliphatic residue, unsubstituted or mono- or trisubstituted; where "aliphatic residue" in each case may be branched or straight, saturated, where "mono- or trisubstituted" with respect to "aliphatic residue" relates, in relation to corresponding residues, to substitution of one or three hydrogen atoms, each independently from other, with at least one substitute selected from a group which includes F, Cl, Br, I, OH, O-C_1-4-aliphatic residue, where "mono- or disubstituted" with respect to "aryl" relates, in relation to corresponding residues, to substitution of one or two hydrogen atoms, each independently from other, with at least one substitute selected from a group which includes F, Cl, Br, I, OH, O-C_1-4-aliphatic residue C_1-4-aliphatic residue. Invention also relates to a pharmaceutical composition based on compound of formula (I) and a method of treating and/or preventing diseases mediated by channels KCNQ2/3 K⁺.

EFFECT: obtaining novel 2-oxy-quinoline-3-carboxamide derivatives having useful biological activity.

8 cl, 2 tbl, 53 ex