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(19)

(11)

2 586 885

(13)

(51)

IPC

C07K7/02(2006-01-01)

C07K5/02(2006-01-01)

C07K16/20(2006-01-01)

A61K38/08(2006-01-01)

A61K38/06(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2014116878/04, 2012-11-07

(24)

Start date

2012-11-07

(22)

Actual filing date

2012-11-07

(45)

Published

2016-06-10

(72)

Inventor

Doroski Matthew DavidMaderna AndreasO'Donnell Christopher JohnSubramanyam ChakrapaniVetelino Beth CooperDushin Russell GeorgeStrop PavelGraziani Edmund Idris

(73)

Holder

Pfizer Inc.

CYTOTOXIC PEPTIDES AND ANTIBODY-DRUG CONJUGATES THEREOF Russian patent published in 2016 - IPC C07K7/02 C07K5/02 C07K16/20 A61K38/08 A61K38/06 A61P35/00

Abstract RU 2586885 C2

FIELD: pharmaceutics.

SUBSTANCE: invention relates to cytotoxic pentapeptides of formula (I), their conjugates antibody-drug and pharmaceutical compositions.

EFFECT: compounds have anti-tumour activity and are intended for treating cancer.

28 cl, 8 dwg, 29 tbl

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RU 2 586 885 C2

Authors

Doroski Matthew David

Maderna Andreas

O'Donnell Christopher John

Subramanyam Chakrapani

Vetelino Beth Cooper

Dushin Russell George

Strop Pavel

Graziani Edmund Idris

Dates

2016-06-10—Published

2012-11-07—Filed